aSPU - Adaptive Sum of Powered Score Test
R codes for the (adaptive) Sum of Powered Score ('SPU' and
'aSPU') tests, inverse variance weighted Sum of Powered score
('SPUw' and 'aSPUw') tests and gene-based and some pathway
based association tests (Pathway based Sum of Powered Score
tests ('SPUpath'), adaptive 'SPUpath' ('aSPUpath') test,
'GEEaSPU' test for multiple traits - single 'SNP' (single
nucleotide polymorphism) association in generalized estimation
equations, 'MTaSPUs' test for multiple traits - single 'SNP'
association with Genome Wide Association Studies ('GWAS')
summary statistics, Gene-based Association Test that uses an
extended 'Simes' procedure ('GATES'), Hybrid Set-based Test
('HYST') and extended version of 'GATES' test for pathway-based
association testing ('GATES-Simes'). ). The tests can be used
with genetic and other data sets with covariates. The response
variable is binary or quantitative. Summary; (1) Single
trait-'SNP' set association with individual-level data ('aSPU',
'aSPUw', 'aSPUr'), (2) Single trait-'SNP' set association with
summary statistics ('aSPUs'), (3) Single trait-pathway
association with individual-level data ('aSPUpath'), (4) Single
trait-pathway association with summary statistics
('aSPUsPath'), (5) Multiple traits-single 'SNP' association
with individual-level data ('GEEaSPU'), (6) Multiple traits-
single 'SNP' association with summary statistics ('MTaSPUs'),
(7) Multiple traits-'SNP' set association with summary
statistics('MTaSPUsSet'), (8) Multiple traits-pathway
association with summary statistics('MTaSPUsSetPath').
